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Future progress will depend on elucidating tumor heterogeneity, optimizing multi-targeted therapeutic regimens, and integrating computational approaches for accelerated drug development

1999 Feb 5;260(3):204-6

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The upregulation of Trx1, however, did not seem to compensate fully for the loss of TRP14 activities, because when assessing cystine reduction using BODIPY-labeled cystine, which becomes fluorescent upon reduction of its disulfide (Pader et al, 2014), TRP14 deletion severely hampered the strong fluorescence seen in control cells (Fig

In our study, we observed the senescence of RPE cells despite the concomitant induction of autophagy following GSH depletion